Objective：To observe the curative effect of intervention of wax therapy with Chinese herbal medicine based on routine treatment and nursing for osteoarthritis of the knee in the early and middle stages.Methods：A total of 80 cases of patients with osteoarthritis of the knee of static blood obstruction type in the early and middle stages were randomly divided into the observation group and the control group，40 cases in each group.Both groups were given routine treatment and nursing，and the observation group was additionally treated with wax therapy with Chinese herbal medicine.Both groups were treated for four weeks.Before and after treatment，the improvement of clinical symptoms and signs was evaluated by the Observation Scale for Symptom and Sign，and the degree of dysfunction was evaluated by Rasmussen Knee Functional Score.The clinical effect in the two groups was compared.Results：After treatment，the total clinical effective rate was 95.0% in the observation group，and 60.0% in the control group，the difference being significant(P＜ 0.05).The scores of numbness，pain，walking，straight leg rising test，patellar reflex and Achilles reflex and the total scores in the two groups were increased when compared with those before treatment(P＜ 0.05)，and the above scores in the observation group were all higher than those in the control group(P ＜ 0.05).The scores of knee function，pain，stability，range of motion，flexion deformity and muscle strength in the Rasmussen Knee Functional Score in the two groups were increased when compared with those before treatment(P＜0.05)，and each score in the observation group was higher than that in the control group(P＜0.05).Conclusion：Based on routine treatment and nursing，the intervention of wax therapy with Chinese herbal medicine for patients with osteoarthritis of the knee in the early and middle stages can effectively relieve the pain of knee and clinical symptoms，promote the recovery of joint function，and play an important role in improving the quality of life.