糖敏方治疗气阴两虚证2型糖尿病临床观察
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R587.1

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上海市中医专科(专病)联盟建设项目[ZY(2018-2020)-FWTX-4011];上海市黄浦区科委资助面上项目(HKM201738)


Clinical Observation of Tangmin Prescription for Type 2 Diabetes Mellitus with Dual Deficiency of Qi and Yin Syndrome
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    摘要:

    目的:观察气阴两虚证 2 型糖尿病患者在辨证施治的基础上选用糖敏方治疗的临床疗效及其对胰岛素敏感性的影响。方法:采用随机对照试验方法,将纳入观察的 61 例气阴两虚证 2 型糖尿病患者分为 2 组。2 组均予饮食及运动控制,对照组 30 例给予二甲双胍片治疗,治疗组 31 例给予糖敏方联合二甲双胍片治疗。2 组均治疗 8 周后比较空腹血糖(FBG)、餐后 2 h血糖 (P2hBG)、糖化血红蛋白 (HbA1c)、空腹胰岛素 (FINS)、胰岛素敏感指数 (ISI)、稳态模型胰岛素抵抗 (HOMA-IR) 指 数、中医证候疗效的变化。结果:治疗组中医证候疗效总有效率 87.10%,优于对照组 50.00% (P<0.05)2 组治疗后 FBG、 P2hBG、HbA1c、FINS、ISI、HOMA-IR 指标均较治疗前改善 (P<0.05),其中P2hBG、FINS、ISI、HOMA-IR 指标及中医症状疗效积分提示治疗组改善更为显著(P<0.05)。结论:糖敏方联合二甲双胍片治疗气阴两虚证 2 型糖尿病疗效优于单用二甲双胍片治疗,能有效降低气阴两虚证 2 型糖尿病患者 P2hBG、改善胰岛素抵抗,提高胰岛素敏感性,在改善中医症状方面具有显著疗效。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Tangmin prescription based on syndrome differentiation for patients with type 2 diabetes mellitus with dual deficiency of qi and yin syndrome and its effect on insulin sensitivity. Methods:A total of 61 cases of patients with type 2 diabetes mellitus with dual deficiency of qi and yin syndrome were divided into the control group and the treatment group according to randomized controlled trials,30 and 31 cases in each group respectively. Both groups were given diet and exercise control;the control group was treated with metformin tablets,and the treatment group was treated with Tangmin prescription combined with metformin tablets. After eight-week treatment,the changes in fasting blood glucose(FBG), postprandial 2- hour blood glucose(P2hBG), hemoglobin A1c(HbA1c), fasting insulin(FINS), insulin sensitivity index(ISI), Homeostasis model assessment of insulin resistance(HOMA- IR) and curative effect of Chinese medicine syndromes in the two groups were compared. Results:The total effective rate of Chinese medicine syndromes was 87.10% in the treatment group,better than that of 50.00% in the control group(P<0.05). After treatment,the indexes of FBG, P2hBG, HbA1c, FINS, ISI and HOMA- IR in the two groups were improved when compared with those before treatment(P < 0.05) , and the improvement of P2hBG,FINS,ISI,HOMA-IR and Chinese medicine syndrome scores in the treatment group was more significant(P<0.05). Conclusion:For patients with type 2 diabetes mellitus with dual deficiency of qi and yin syndrome,the therapy of Tangmin prescription combined with metformin tablets has better curative effect than that of simple metformin tablets. It can effectively reduce their P2hBG,improve insulin resistance and insulin sensitivity,which has significant curative effect in improving Chinese medicine symptoms.

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邵文妍,杨丽鸣,冯继明,齐慧娟,汪玖瑛.糖敏方治疗气阴两虚证2型糖尿病临床观察[J].新中医,2020,52(22):73-76

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  • 在线发布日期: 2020-11-27
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