Abstract：Objective：To observe the effect of Tongmai Huoxue Yiqi prescription in preventing deep venous thrombosis after surgery of senile intertrochanteric fracture. Methods： A total of 120 cases of senile patients undergoing surgery of intertrochanteric fracture were divided into the control group and the observation group according to the random number table method，60 cases in each group. The control group was given routine western medicine treatment and functional exercise for preventing deep venous thrombosis，and the observation group was additionally given Tongmai Huoxue Yiqi prescription for prevention and treatment based on the treatment of the control group. Both groups were treated for fifteen days. Before surgery as well as on the 1st and 15th days after surgery，the changes in hemorheology and D-dimer were compared between the two groups. Blood vessels of both lower extremities were examined by color Doppler ultrasound every day，and deep venous thrombosis was observed. The occurrence of adverse reactions during treatment was recorded. Results：On the 1st day after surgery， the D-dimer levels in the two groups were increased when compared with those before treatment (P＜0.05)；on the 15th day after surgery，the levels in the two groups were decreased when compared with those on the 1st day after treatment(P＜0.05)；the level in the observation group was lower than that in the control group(P＜0.05). Before treatment， when compared indexes including whole blood viscosity， plasma viscosity and fibrinogen between the two groups，there was no significance in the difference(P＞0.05). After treatment，the levels of whole blood viscosity，plasma viscosity and fibrinogen in the two groups were decreased when compared with those before treatment，and each index in the observation group was lower than that in the control group，differences being significant(P＜0.05). On the 15th day after surgery，the deep venous thrombosis incidence was 1.67%(1/60) in the observation group，lower than that of 11.67%(7/60) in the control group，the difference being significant(P＜0.05). Conclusion：Tongmai Huoxue Yiqi prescription can effectively prevent deep venous thrombosis after surgery of senile intertrochanteric fracture without any adverse reaction，which can be further promoted and applied.