Abstract： Objective： To observe the clinical effect of Qufu Shengxin ointment and dressing change combined with antibiotics for patients after operation for perianal abscess. Methods：A total of 60 cases of patients after operation for perianal abscess were randomly divided into the observation group and the control group，30 cases in each group. After operation， the control group was given oral administration of ciprofloxacin after routine dressing change，and the observation group was given external application of Qufu Shengxin ointment combined with oral administration of ciprofloxacin. The wound pain， wound exudate，growth of granulation and wound healing time in the two groups were observed and compared；the clinical effect in the two groups was calculated. Results：The cure rate was 90.00% in the observation group and 43.33% in the control group，the difference being significant(P＜0.05). On the 7th，14th and 28th day after operation respectively，VAS scores in the two groups were significantly decreased when compared with those before treatment(P＜0.05)；on the 28th day after treatment，VAS score in the observation group was significantly lower than that in the control group(P＜0.05). On the 7th，14th and 28th day after operation respectively，the scores of wound exudate in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the scores at each time point in the observation group were lower than those in the control group(P＜0.05). On the 7th， 14th and 28th day after operation respectively， the scores of granulation growth in the observation group were lower than those in the control group，the difference being significant(P＜0.05). The average wound healing time in the observation group was shorter than that in the control group， the difference being significant(P＜0.05). Conclusion：The application of Qufu Shengxin ointment combined with ciprofloxacin for patients after operation for perianal abscess can reduce the pain and accelerate wound healing，with significant clinical effect.