Abstract： Intervertebral disc disease(IVDD) is closely related to nuclear factor κB(NF- κB) signaling pathway. Curcumin can inhibit NF- κB signaling pathway to intervene the influencing factors of IVDD，so that the degeneration process can be slowed down. Based on literature， the authors reviewed the related factors involved in the regulation of IVDD by NF- κB signaling pathway，and the related research progress of intervention of IVDD by NF-κB inhibitors represented by curcumin.