Abstract： Objective： To observe the clinical effect of Chaihu Guizhi Ganjiang tang and Danggui Shaoyao powder combined with western medicine for chronic hepatitis B(CHB). Methods：A total of 160 cases of patients with CHB of liver depression and qi stagnation as well as dampness obstruction in the middle energizer type were divided into the observation group and the control group according to the random number table method， 80 cases in each group. Both groups were treated with oral administration of entecavir dispersible tablets and Wuzhi tablets，and the observation group was additionally treated with Chaihu Guizhi Ganjiang tang and Danggui Shaoyao powder. Both groups were treated for four months and following-up for three months. After treatment and after three months of following-up respetively，hepatitis B virus e antigen (HBeAg) in serum was detected，and the responses of serology and biochemistry were counted. Before and after treatment， the indexes of the liver function such as alanine aminotransferase(ALT)， aspartate aminotransferase(AST) and total bilirubin (TBil) in serum were detected；the scores of liver depression and qi stagnation syndrome were evaluated. The clinical effect in the two groups was compared. Results： After treatment， the curative effect of Chinese medicine syndrome in the observation group was better than that in the control group(P＜0.05). The Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.01)，and the score in the observation group was lower than that in the control group(P＜0.01). After treatment and after following-up respectively，the negative rate of HBeAg and the recovery rate of ALT in serum in the observation group were higher than those in the control group(P＜0.05，P＜0.01). The levels of ALT，AST and TBil in serum in the two groups were decreased when compared with those before treatment(P＜ 0.01)， and the above three levels in serum in the observation group were lower than those in the control group(P＜0.01). Conclusion： The therapy of modified Chaihu Guizhi Ganjiang tang and Danggui Shaoyao powder combined with entecavir dispersible tablets and Wuzhi tablets in treating CHB patients of liver depression and qi stagnation as well as dampness obstruction in the middle energizer type can improve the negative rate of HBeAg and the curative effect of Chinese medicine syndrome，protect the liver function，and reduce symptoms，with stable and lasting curative effect.