Abstract： Objective： To observe the effect of the therapy of Huangqi Sijunzi tang combined with blood component transfusion on the immune function of patients after the surgery for liver cancer. Methods：A total of 50 patients with liver cancer were randomly divided into two groups， 25 cases in each group. Both groups were intervened with mitomycin， fluorouracil，epirubicin and iodized oil. After the surgery，the control group was treated with compound glycyrrhizin injection； the observation group was treated with Huangqi Sijunzi tang combined with blood component transfusion. The clinical effect and the improvement of immune function，Chinese medicine syndrome score and quality of life in the two groups before and after treatment were observed and compared. Results： The total effective rate was 92.0% in the observation group and 68.0% in the control group，the difference being significant(P＜0.05). After treatment，the levels of CD3+，CD4+，CD8+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group，the difference being significant (P＜0.05). After treatment， the scores of abdominal mass， paleness of lips and cheeks， edema of lower limbs， spontaneous sweat and night sweat in the observation group were significantly lower than those in the control group， differences being significant(P＜0.05). After treatment，the scores of quality of life including physiology，emotion，daily life and social life in the observation group were significantly higher than those in the control group， the difference being significant(P＜0.05). Conclusion： The therapy of Huangqi Sijunzi tang combined with blood component transfusion has significant therapeutic effect in treating patients after the surgery for liver cancer，which can effectively improve the immune function，clinical symptoms and the quality of life and is worthy of clinical application.