Abstract： Objective： To observe the curative effect of Qingfei Tongfu prescription for acute exacerbation of chronic obstructive pulmonary disease(COPD) of chronic bronchitis type. Methods：A total of 90 patients with acute exacerbation of COPD of chronic bronchitis type were randomly divided into Group A，Group B and Group C，30 patients in each group(P＜ 0.05). Group A received conventional treatment；Group B received conventional treatment combined with azithromycin，and Group C received conventional treatment combined with azithromycin as well as Qingfei Tongfu prescription. The three groups were compared in terms of clinical effect and pulmonary function after treatment. Results：After treatment，Group C had the best clinical effect， with the total effective rate of 93.33% ， followed by Group B(80.00% )， and Group A the worst， the difference being significant(P＜0.01). After treatment， Group C had better forced vital capacity(FVC)， forced expiratory volume in one second(FEV1) and the rate in one second(FEV1%) than Group B and Group A，the difference being significant (P＜0.05). The FVC，FEV1 and FEV1% in Group B were better than those in Group A(P＜0.05). Conclusion：The therapy of Qingfei Tongfu prescription combined with azithromycin as well as conventional treatment has the most significant therapeutic effect in treating senile patients with acute exacerbation of COPD of chronic bronchitis type， followed by conventional treatment combined with azithromycin，and the conventional treatment the least.