Abstract：Objective：To observe the clinical effect of Jianpi Yuyang prescription combined with rabeprazole triple therapy for peptic ulcer. Methods：A total of 80 cases of patients with peptic ulcer were selected，and divided into the control group and the observation group according to the random number table method，40 cases in each group. The control group was treated with rabeprazole triple therapy，and the observation group was additionally given Jianpi Yuyang prescription based on the treatment of the control group. Both groups were treated for four weeks. The clinical effect in the two groups was observed，the expression levels of prostaglandin E2(PGE2)，vascular endothelial growth factor(VEGF) and epidermal growth factor(EGF) in the two groups were compared， and the adverse reactions as well as the recurrence rate of ulcer in three months after treatment were recorded. Results：The total effective rate was 95.0% in the observation group，higher than that of 85.0% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the symptom scores between the two groups(P＞0.05). After treatment， the scores of symptoms including stomachache，belching and gastric discomfort with acid regurgitation，dry mouth and bitter taste， and abnormal defecation in the two groups were decreased when compared with those before treatment(P＜0.05)， and the scores of all the above symptoms in the observation group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of PGE2，VEGF and EGF in serum between the two groups(P＞0.05). After treatment， the above levels in the two groups were increased when compared with those before treatment(P＜0.05)； the above levels in the observation group were higher than those in the control group(P＜0.05). The incidence of adverse reactions was 5.0% in the observation group，lower than that of 17.5% in the control group，the difference being significant(P＜0.05). The recurrence rate of ulcer was 5.0% in the observation group， lower than that of 15.0% in the control group，the difference being significant(P＜0.05). Conclusion：The therapy of Jianpi Yuyang prescription combined with rabeprazole triple therapy has significant clinical effect in treating peptic ulcer，which is worthy of clinical promotion and application.