Abstract： Objective： To study the effect of liver- soothing method combined with Ziyin Bushen tang on endometrial receptivity， the usage of gonadotropin and pregnancy outcome in patients with low ovarian response in the cycle of the assisted reproductive technology of in vitro fertilization-embryo transfer(IVF-ET). Methods：A total of 180 cases of patients with low ovarian response in IVF- ET cycle， who were in accordance with the inclusion criteria， were divided into the combination group，the liver-soothing method group and the control group according to the randomized principle. The control group was treated with controlled ovarian hyperstimulation；the liver- soothing method group was additionally treated with liver-soothing method based on the treatment of the control group；the combination group was additionally treated with Ziyin Bushen tang based on the treatment of the liver-soothing method group. The starting dosage，using days and total dosage of GnRH- a， the levels of estradiol(E2)， luteinizing hormone(LH) and progesterone(P) in serum on the day when applying the human chorionic gonadotropin，endometrial receptivity，successful pregnancy rate and adverse pregnancy outcomes in the three groups were observed and compared. Results：Compared the starting dosage，using days and total dosage of GnRH-a， the levels of E2， P and LH in serum on the day when applying the human chorionic gonadotropin， full thickness of endometrium and uterine morphology in the three groups， there was significance in differences(P＜0.05). After multiple comparison，the starting dosage，using days and total dosage of GnRH-a in the combination group were significantly lower than those in the other two groups(P＜0.05)； the levels of E2， P and LH in serum on the day when applying the human chorionic gonadotropin as well as the full thickness of endometrium in the combination group were significantly higher than those in the other two groups(P＜0.05)；the clinical pregnancy rate was 71.67% in the combination group，higher than that of 51.67% in the liver- soothing method group and 41.67% in the control group(P＜0.05)； there were significant differences being found in malformation，abortion，premature delivery and early embryonic death in the three groups(P＜0.05)，and the cases of abnormal pregnancy in the combination group were much less than those in the other two groups(P＜0.05). Conclusion：The therapy of liver-soothing method combined with Ziyin Bushen tang for patients with low ovarian response in IVF- ET cycle can effectively improve the endometrial receptivity，successful pregnancy rate and pregnancy outcome，and reduce the usage of gonadotropin.