Abstract： Objective： To observe the clinical effect of Shenqi Fuzheng injection combined with docetaxel for breast cancer. Methods：Divided 98 cases of patients with breast cancer into the control group and the combination group according to random number table， 49 cases in each group. Both groups received routine chemotherapy with docetaxel and cyclophosphamide，while the combination group additionally received Shenqi Fuzheng injection. Compared the changes of Tlymphocyte subsets，the expression of dendritic cell(DC) surface molecules，the changes in levels of serum tumor markers and the occurrence of adverse reactions in both groups before and after treatment. Results：Before treatment，there was no significant difference being found when comparing the levels of CD3+，CD4+，CD8+ and CD4+/CD8+ between the two groups (P＞0.05). After treatment， the levels of CD3 + ， CD4 + and CD4 +/CD8 + in both groups were significantly higher than those before treatment， the levels of CD8 + were lower than those before treatment， and each index above in the combination group was improved more obviously， differences being significant(P＜0.05). Before treatment， there was no significant difference being found when comparing the levels of CD80， CD83 and CD86 between the two groups(P＞0.05). After treatment，the levels of CD80，CD83 and CD86 in both groups were significantly higher than those before treatment，and each index above in the combination group was increased more obviously， differences being significant(P＜0.05). Before treatment， there was no significant difference being found when comparing the levels of serum CEA， CA125 and CA153 between the two groups(P＞0.05). After treatment， the levels of serum CEA， CA125 and CA153 in both groups were significantly lower than those before treatment， and each index above in the combination group was decreased more obviously， differences being significant(P＜0.05). There was significant difference being found when comparing adverse reactions of grade III to IV in the combination group with those in the control group(χ 2=6.513， P＜0.05). Conclusion： The application of Shenqi Fuzheng injection combined with docetaxel has exact effect in treating patients with breast cancer， which can improve cellular immune function，inhibit tumor growth and reduce the adverse reactions due to chemotherapy.