Abstract： Objective： To study the characteristics of medication and compatibility as well as treatment principles and methods of the past scholars in treating stroke by pure Chinese herbal medicine，and to compare it with modern medication rule of integrated Chinese and western medicine and make an analysis. Methods：Ancient and modern prescriptions of pure Chinese herbal medicine for stroke in Classics of Traditional Chinese Medicine 5.0 were collected; the standardized database was established by Microsoft Office Excel 2013; the frequency analysis， correlation analysis and cluster analysis on prescriptions in the database were performed by SPSS Statistics25 and SPSS Modeler18.0. Results： In the study， 429 provisions， 1 330 prescriptions and 528 Chinese herbal medicines were included， with a total frequency of 15 689 times.There were 13 Chinese herbal medicines whose frequency is higher than 20% . The categories of Chinese herbal medicine whose frequency is more than 1 000 times include exterior- releasing medicinal， deficiency- nourishing medicinal， winddampness dispelling medicinal， liver- pacifying and wind- extinguishing medicinal， blood- activating and stasis- resolving medicinal as well as phlegm- resolving， cough- suppressing and panting- calming medicinal. Under the condition of 20% support and 50% confidence，20 strongly correlated medicine pairs were obtained. 4 cluster groups were obtained from top 20 high-frequency medicines in cluster analysis. Conclusion：The basic methods of prescription-composing and medication of the past scholars in treating stroke are extinguishing wind and resolving phlegm， warming yang to free the collateral vessels， dispelling wind and promoting blood circulation， as well as tonifying qi to fortify the spleen. The application of exterior- releasing and wind- dispelling medicinal， yang- warming and blood- activating medicinal and orifice- opening and resuscitation-inducing medicinal which are related to the Classics of Traditional Chinese Medicine 5.0 may be necessary for modern doctors to pay attention to.