Abstract：Objective：To observe the clinical effect of Shugan Yiyang capsules combined with paroxetine hydrochloride tablets for premature ejaculation. Methods： A total of 94 cases of patients with premature ejaculation were selected and divided into the control group and the observation group according to the random number table method， 47 cases in each group. The control group was treated with paroxetine hydrochloride tablets，and the observation group was additionally given oral administration of Shugan Yiyang capsules based on the treatment of the control group. The clinical effect in the two groups was compared， Chinese Index of Sexual Function for Premature Ejaculation(CIPE- 5) and intravaginal ejaculation latency time(IELT) were evaluated，and the levels of leptin and 5- hydroxytryptamine(5- HT) in serum，the changes of the levels of acid phosphatase(ACP) and α-glucosidase(α-Glu) in seminal plasma as well as the adverse reactions were detected.Results： The total effective rate was 93.62% in the observation group， higher than that of 72.34% in the control group (P＜0.05). After treatment， CIPE- 5 scores and IELT in the two groups were increased when compared with those before treatment(P＜0.05)， and the above indexes in the observation group were higher than those in the control group(P＜0.05).After treatment， the levels of leptin in serum in the two groups were decreased when compared with those before treatment，while 5- HT levels were increased when compared with those before treatment；the level of leptin in serum in the observation group was lower than that in the control group，while 5-HT level was higher than that in the control group；differences being significant(P＜0.05). After treatment， the levels of ACP and α- Glu in seminal plasma in the two groups were increased when compared with those before treatment(P＜0.05)，and the above levels in the observation group were higher than those in the control group(P＜0.05). The incidence of adverse reactions in the observation group was 8.51% ，lower than that of 31.91% in the control group(P＜0.05). Conclusion：The therapy of Shugan Yiyang capsules combined with paroxetine hydrochloride tablets has good curative effect in treating premature ejaculation， which can reduce the level of leptin in serum，improve the levels of 5-HT in serum and ACP and α-Glu in seminal plasma，with few adverse reactions and good medication safety.