Abstract： Objective： To discuss the clinical effect of Jianpi Tongluo prescription combined with chemotherapy for patients with advanced esophageal carcinoma and its effect on quality of life. Methods：A total of 83 cases of patients with advanced esophageal carcinoma were divided into the control group and the observation group according to the random number table method， 40 and 43 cases in each group respectively. The control group was treated with routine chemotherapy，and the observation group was additionally treated with Jianpi Tongluo prescription based on the treatment of the control group. The clinical effect in the two groups was compared， and the Chinese medicine syndrome scores and quality of life in the two groups were observed. Results：The total effective rate was 88.37% in the observation group，higher than that of 67.50% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P＞0.05). After treatment， the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment， and the score in the observation group was lower than that in the control group， differences being significant(P＜0.05). After treatment， the levels of CD4 + and CD4 +/CD8 + in the observation group were increased when compared with those before treatment，and the level of CD8+ was decreased(P＜0.05)；the levels of CD4+ and CD4+/CD8+ in the control group were decreased when compared with those before treatment，and the level of CD8+ was increased (P＜0.05). The levels of CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group，and the level of CD8 + was lower(P＜0.05). Before treatment， there was no significant difference being found in the comparison of Karnofsky scores between the two groups(P＞0.05). After treatment，the Karnofsky scores in the two groups were increased when compared with those before treatment， and the score in the observation group was higher than that in the control group， differences being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of scores of quality of life between the two groups(P＞0.05). After treatment，the scores of quality of life in the two groups were increased when compared with those before treatment，and the score in the observation group was higher than that in the control group，differences being significant(P＜0.05). Conclusion：Jianpi Tongluo prescription combined with chemotherapy in treating patients with advanced esophageal carcinoma can effectively improve their clinical symptoms，immune function and quality of life.