Abstract：Objective：To observe the effect of Chinese and western medicine combined with extended nursing measures on treatment and quality of life in patients with tuberculosis. Methods： A total of 120 cases of patients initially treating tuberculosis were divided into the observation group and the control group according to different nursing measures，64 and 56 cases in each group respectively. Both groups were given routine antituberculous therapy and nursing measures including instruction and education， psychological nursing care and establishment of good living habits. After discharge， extended nursing measures were performed by telephone and Wechat，and at the same time，the observation group was given point application by Chinese medicine for 12 weeks and diet guidance. Both groups were treated for six months. During the sixmonth treatment，the compliance of medication，reexamination on time and diet in the two groups was evaluated. Before and after treatment， the symptoms and adverse reactions were evaluated， and the quality of life was assessed by World Health Organization Quality of Life-BREF(WHOQOL-BREF). Results：During the six-month treatment，the compliance of medication，reexamination on time and diet in the observation group was higher than that in the control group(P＜0.05，P＜0.01). After treatment for one to six months，the symptom scores of tuberculosis in the two groups were decreased when compared with those before treatment(P＜0.01)，and the score in the observation group was lower than that in the control group(P＜0.01). The score of adverse reactions in the observation group was lower than that in the control group(P＜0.01).After treatment for three months， the WHOQOL- BREF scores in the two groups were decreased when compared with those before treatment(P＜0.01). After treatment for six months，the WHOQOL-BREF score in the control group was lower than that before treatment(P＜0.01)， and no significant difference was found in the comparison of the score in the observation group before and after treatment(P＞0.05). After treatment for three and six months respectively，the WHOQOLBREF scores in the observation group were higher than those in the control group(P＜0.01). Conclusion：The intervention of Chinese and western medicine combined with extended nursing measures for patients with tuberculosis undergoing antituberculous therapy can improve their compliance of medication，reexamination and diet，relieve symptoms and adverse reactions and stabilize or improve their quality of life.