Abstract： Objective： To observe the clinical effect of self- made Yi'nao Anshen prescription combined with western medicine for epilepsy. Methods： A total of 68 cases of patients with epilepsy were randomly divided into two groups， 34 cases in each group. On the basis of routine treatment of acute attack， the control group was treated with levetiracetam tablets， and the observation group was additionally treated with Yi'nao Anshen prescription based on the treatment of the control group. Both groups were treated for four weeks. The curative effect of Chinese medicine syndromes and recovery effect of electroencephalogram in the two groups were observed and compared. Results：The total effective rate of Chinese medicine syndromes was 94.12% in the observation group and 79.41% in the control group，the difference being significant (P＜0.05). Compared with that before treatment and that in the control group after treatment respectively，the relative power of α band in electroencephalogram in the observation group after treatment was significantly increased(P＜0.05)， and the relative power values of β， δ and θ bands were significantly decreased(P＜0.05). In the control group， there was no significant change in relative power values of each band in electroencephalogram before and after treatment(P＞0.05). Conclusion： The therapy of Yi'nao Anshen prescription combined with levetiracetam tablets for epilepsy can promote the recovery of brain electrical activity，with significant clinical effect.