Abstract：Objective：To observe the clinical effect of Bushen Tiaojing serial prescriptions combined with norethisterone for dysfunctional uterine bleeding and its effect on sexhormone levels and endometrial thickness. Methods： A total of 80 cases of patients with dysfunctional uterine bleeding were randomly divided into the control group and the observation group， 40 cases in each group. The control group was simply treated with norethisterone，and the observation group was additionally treated with Bushen Tiaojing serial prescriptions(No.1 and No.2 prescription) based on the treatment of the control group. The changes in levels of luteinizing hormone(LH)，follicle stimulating hormone(FSH)，estrogen(E2) and phosphorus(P) as well as endometrial thickness before and after treatment， and the clinical effect in the two groups were observed and compared. Results： The total effective rate was 95% in the observation group and 77.5% in the control group， the difference being significant(P＜0.05). After treatment，the levels of LH，FSH，E2 and P in serum as well as endometrial thickness in the two groups were lower than those before treatment(P＜0.05)，the improvement of the above indexes in the observation group was more significant than that in the control group(P＜0.05). Conclusion：Bushen Tiaojing serial prescriptions combined with norethisterone for dysfunctional uterine bleeding can significantly improve sexhormone levels， endometrial thickness and clinical effect.