Abstract： Objective： To observe the clinical effect of Jianpi Jiedu tang combined with western medicine for recurrent oral ulcer(ROU) of spleen- stomach qi deficiency type. Methods： A total of 90 cases of ROU patients who met the study criteria were randomly divided into the western medicine group and the combination group， 45 cases in each group. The western medicine group was given dexamethasone and vitamin B1， B2 and C and other routine treatment， and the combination group was additionally treated with self- made Jianpi Jiedu tang based on routine western medicine treatment. Both groups were treated for two to three courses and followed up for six months. After treatment， the healing time of ulcer， the scores of Visual Analogue Scale(VAS) and Chinese medicine symptoms as well as recurrence rates in the two groups were compared；the clinical effect and safety were evaluated. Results：The healing time in the combination group was shorter than that in the western medicine group(P＜0.05). After treatment， the scores of VAS and Chinese medicine symptoms in the two groups were decreased(P＜0.05). Compared with those in the western medicine group，the scores of VAS and Chinese medicine symptoms in the combination group after treatment were lower，the difference being significant (P＜0.05). The total effective rate was 95.56% in the combination group and 80.00% in the western medicine group， the difference being significant(P＜0.05). There was no significant difference being found in the comparison of the recurrence rates after three-month follow-up between the two groups(P＞0.05)，and the recurrence rate in the combination group after six- month follow- up was lower than that in the western medicine group，the difference being significant(P＜0.05). There was no obvious adverse reaction in the two groups during the treatment， and the safety was good. Conclusion： The treatment of ROU from the perspective of integrated Chinese and western medicine can effectively shorten the healing time of ulcer，relieve pain and reduce the recurrence，with good safety and significant clinical effect.