Abstract：Objective：To observe the clinical effect of Chinese medicine nursing combined with routine medical measures for type 2 diabetes mellitus(T2DM) complicated with hyperlipidemia. Methods：A total of 116 cases of patients were randomly divided into the control group and the observation group，58 cases in each group. Both groups were given drugs to control blood glucose and lipid，and patients were managed by chronic disease management platform and given guidance including health education，body weight reduction，dietary structure adjustment and exercise mode. The observation group was given guidance of Chinese medicine diet and psychological nursing. Both groups were treated for 12 weeks，and patients received nursing guidance at least three times a week. Before and after treatment， the levels of triglyceride(TG)， total cholesterol (TC)，high density lipoprotein cholesterol(HDL-C)，low density lipoprotein cholesterol(LDL-C)，fasting blood glucose(FBG)， postprandial 2 h blood glucose(P2hBG) and glycosylated hemoglobin(HbA1c) were detected，and the standard-reaching rates of LDL- C were counted. After treatment， the nursing satisfaction and Framingham Risk Score(FRS) were evaluated. Results：After treatment，the standard-reaching rate of LDL-C in the observation group was higher than that in the control group(P＜0.05). The levels of TC， TG and LDL- C in the two groups were decreased when compared with those before treatment(P＜0.01)，and the levels of HDL-C were increased(P＜0.01). The levels of TC，TG and LDL-C in the observation group were lower than those in the control group(P＜0.05)，and the level of HDL-C was higher(P＜0.05). The levels of FBG， P2hBG and HbA1c in the two groups were decreased when compared with those before treatment(P＜0.01)，and the levels of P2hBG and HbA1c in the observation group were lower than those in the control group(P＜0.05). The risk level of cardiovascular system in the observation group was lighter than that in the control group(P＜0.05)，and nursing satisfaction was higher(P＜0.05). Conclusion：Based on routine medicine treatment and nursing，the additional application of guidance of Chinese medicine diet and psychological nursing for patients with T2DM complicated with hyperlipidemia can further regulate the blood lipid level and glucose metabolism，relieve risk level of cardiovascular system and improve the standard-reaching rate of LDL-C and nursing satisfaction.