Abstract： Objective： To observe the preventive and curative effect of electroacupuncture combined with point application with Chinese herbal medicine based on routine nursing on adverse reactions of painless electronic gastroscope. Methods：A total of 160 cases of patients undergoing painless electronic gastroscope were randomly divided into the control group and the observation group， 80 cases in each group. Both groups were given routine comprehensive nursing measures， and the observation group was additionally treated with electroacupuncture and point application with Chinese herbal medicine. During the gastroscopy course， the incidences of swallowing， nausea and vomiting， gastrointestinal spasm，twisting motion of limbs，irritating cough，restlessness and respiratory depression were recorded. At 5 min before anesthesia(T1)，at the beginning of examination(T2)，5 min after the beginning of examination(T3) and 5 min after examination (T4) respectively， systolic blood pressure(SBP) and diastolic blood pressure(DBP)， heart rate(HR)， respiratory rate(RR) and oxygen saturation(SPO2) were recorded. The duration of gastroscopy， the usage of propofol and the awakening time were recorded. After examination and before leaving the examination room， the satisfaction with examination was evaluated. Results：The preventive and curative effect of reactions to examination in the observation group was better than that in the control group(P＜0.05)，and the cumulative incidence of reactions to examination was lower(P＜0.01)，and the satisfaction with examination was higher(P＜0.05). In the control group，at T2 and T3，SBP，DBP，HR，RR and SPO2 were decreased when compared with those at T1(P＜0.05)；at T4，SBP and DBP were lower than those at T1(P＜0.05)；compared HR，RR and SPO2 with those at T1， there was no significance in the difference(P＞0.05). In the observation group， at T2， SBP， DBP，RR and SPO2 were decreased when compared with those at T1(P＜0.05)；at T3，SBP，DBP，HR，RR and SPO2 were decreased when compared with those at T1(P＜0.05)；compared the indexes at T4 with those at T1，there was no significance in the difference(P＞0.05). In the observation group，at T2，SBP，DBP，HR and SPO2 were higher than those in the control group(P＜0.05)；at T3，SBP，DBP，HR，RR and SPO2 were higher than those in the control group(P＜0.05)；at T4，SBP was higher than that in the control group(P＜0.05). There was no significant difference being found in the comparison of duration of gastroscopy between the two groups(P＞0.05). The usage of propofol in the observation group was less than that in the control group(P＜0.05)， and the awakening time was earlier(P＜0.05). Conclusion： Based on routine nursing， the additional application of electroacupuncture combined with point application with Chinese herbal medicine can reduce the incidence of adverse reactions of painless electronic gastroscope， and stabilize vital signs of patients， which has a better preventive and curative effect.