Abstract： Objective： To observe the effect of Chinese medicine constitution- regulating nursing based on physique differentiation in nursing management of patients with type 2 diabetes. Methods：Selected 160 cases of patients with type 2 diabetes，and divided them into the control group and the observation group according to random number table，80 cases in each group. The control group received medicine and routine nursing management，while the observation group additionally received Chinese medicine constitution- regulating nursing based on physique differentiation. Compared the scores of compliance behaviors(taking medicine as directed by medical orders， regular reexamination， mastering knowledge about disease and proper diet) and quality of life(physiological dimension，psychological dimension and treatment dimension) in the two groups after intervention， and investigated the degree of satisfaction. Results： After intervention， each score of compliance behaviors and each score of quality of life in the observation group were obviously higher than those in the control group， difference being significant(P＜0.05). The degree of satisfaction in the observation group was obviously higher than that in the control group，difference being significant(P＜0.05). Conclusion：The application of Chinese medicine constitutionregulating nursing based on phyisque differentiation has good effect in nursing management of patients with type 2 diabetes， and assists in enhancing compliance behaviors，thus better improving the quality of life.