清心导赤汤联合常规西药治疗口腔扁平苔藓心脾积热证临床研究
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R781.5

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Clinical Study on Qingxin Daochi Tang Combined with Routine Western Medicine for Oral Lichen Planus with Accumulated Heat in Heart and Spleen Syndrome
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    摘要:

    目的:观察清心导赤汤联合常规西药治疗口腔扁平苔藓心脾积热证的效果。方法:纳入90例口腔扁平苔藓心脾积热证患者,采用单盲随机分组法分为西药组和联合组,2组各45例。其中西药组给予醋酸曲安奈德联合利多卡因方案治疗,联合组在西药组治疗基础上加予清心导赤汤治疗,持续治疗12周,观察2组治疗效果。结果:治疗后,2组症状体征评分较治疗前明显下降,联合组治疗后评分低于西药组(P<0.05)。治疗2、4周后,联合组视觉模拟评分法(VAS) 评分低于治疗前及西药组治疗后,差异有统计学意义(P<0.05)。治疗后,联合组缓解总有效率97.78%,西药组为84.44%(P<0.05)。2组治疗期间均无明显不良反应发生,联合组6个月复发率11.63%(5/43),低于西药组的30.56%(11/36),差异有统计学意义(P<0.05)。结论:清心导赤汤联合西药治疗口腔扁平苔藓心脾积热证可显著改善患者的症状体征,增益临床疗效和降低复发风险,且安全性好。

    Abstract:

    Abstract: Objective: To observe the effect of Qingxin Daochi Tang combined with routine western medicine for oral lichen planus with accumulated heat in the heart and spleen syndrome. Methods: A total of 90 cases of patients with oral lichen planus with accumulated heat in the heart and spleen syndrome were enrolled and divided into the western medicine group and the combination group according to single-blind randomized group method,45 cases in each group. The western medicine group was given triamcinolone acetonide acetate combined with lidocaine, and the combination group was additionally given Qingxin Daochi Tang. Both groups were continuously treated for 12 weeks. The curative effect in the two groups was observed. Results: After treatment, the scores of symptoms and signs in the two groups were significantly decreased when compared with those before treatment,and the scores in the combination group were lower than those in the western medicine group(P<0.05). After two and four weeks of treatment,the scores of Visual Anaalogue scale(VAS) in the combination group were lower than those before treatment and in the western medicine group after treatment, the difference being significant(P<0.05). After treatment, the total effective rate of remission was 97.78% in the combination group and 84.44% in the western medicine group(P<0.05). During treatment,no significant adverse reactions occurred in the two groups. The recurrence rate in six months was 11.63%(5/43) in the combination group,lower than that of 30.56%(11/36) in the western medicine group,the difference being significant(P<0.05). Conclusion:The therapy of Qingxin Daochi Tang combined with western medicine in treating oral lichen planus with accumulated heat in the heart and spleen syndrome,can significantly improve symptoms and signs of patients, gain the clinical effect and reduce the recurrence risk, with good safety.

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侯玉明.清心导赤汤联合常规西药治疗口腔扁平苔藓心脾积热证临床研究[J].新中医,2020,52(12):32-34

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  • 在线发布日期: 2020-06-15
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