Abstract： Objective： To observe the clinical effect of Juanbi tang and tuina manipulation combined with western medicine for knee osteoarthritis at attack stage with cold-dampness obstruction syndrome. Methods：A total of 120 cases of patients were divided into the control group and the observation group according to the random number table method ，60 cases in each group. Both groups were given oral administration of celecoxib capsules and glucosamine hydrochloride capsules，and external application of diclofenac sodium gel to the knee joint；the observation group was additionally treated with modified Juanbi tang and tuina manipulation. Both groups were treated for four weeks. Before and after treatment，the symptoms and function of knee joint were evaluated by Western Ontario and McMaster University Osteoarthritis Index (WOMAC)；the degrees of walk-associated pain，rest pain and swelling in the knee joint were evaluated by Visual Analogue Scale(VAS)；the quality of life of patients was evaluated by Short-form Arthritis Impact Measurement Scales 2(AIMS2-SF). Compared the clinical effect between the two groups. Results：After treatment，the clinical effect in the observation group was better than that in the control group(P＜0.05). The WOMAC scores of the three dimensions including pain，stiffness and joint function as well as the total scores in the two groups were decreased when compared with those before treatment(P＜0.01)；the above scores in the observation group were lower than those in the control group(P＜0.01). The scores of walkassociated pain， rest pain and swelling degree in the two groups were decreased when compared with those before treatment(P＜0.01)； the above scores in the observation group were lower than those in the control group(P＜0.01). The AIMS2- SF scores of body， symptom， influence， society and work as well as the total scores in the two groups were increased when compared with those before treatment(P＜0.01)；the above scores in the observation group were higher than those in the control group(P＜0.01). Conclusion： Based on the intervention of routine western medicine， the therapy of modified Juanbi tang combined with tuina manipulation for patients with knee osteoarthritis at attack stage with colddampness obstruction syndrome can further relieve the joint swelling and pain，promote the recovery of joint function，and improve the quality of life of patients，whose clinical effect is better than that of simple western medicine.