Abstract：Objective：To observe the clinical effect and value of Xue's Lijin Tongluo Bushen method for calcaneodynia. Methods：A total of 120 cases of patients with calcaneodynia who met the inclusion criteria were selected as the subjects to conduct a clinical control study，and they were divided into two groups according to the random number table method，60 cases in each group. The control group was given triamcinolone acetonide， lidocaine， vitamin B1 and vitamin B12 in 0.9% sodium chloride injection for local blocking therapy； the observation group was treated with Xue's Lijin Tongluo Bushen method. The scores of clinical symptoms，signs and pain before and after treatment were compared；the clinical effect in the two groups was evaluated and compared； the changes in quality of life before and after treatment were compared； the safety of different schemes was compared. Results： During the observation period， the expulsion rate was 1.67% in the observation group and 5.00% in the control group；a total of 59 cases in the observation group and 57 cases in the control group were involved in the statistics. After treatment，the scores of clinical symptoms and signs including pain，tenderness， walking function and swelling as well as the total scores in the two groups were increased(P＜0.05)，and the above scores in the observation group were higher than those in the control group(P＜0.05)； the VAS scores in the two groups were decreased(P＜0.05)， and the score in the observation group was lower than that in the control group(P＜0.05). There was significant difference being found in the comparison of the distribution of clinical effect between the two groups(P＜0.05)，and the total effective rate was 96.61% in the observation group，higher than that 82.46% in the control group(P＜0.05). After treatment，the scores of quality of life including physical health and mental health as well as the total scores in the two groups were increased，differences being significant(P＜0.05)；the above scores in the observation group were higher than those in the control group(P＜0.05)；there was significant difference being found in the comparison of distribution and classification of safety between the two groups(P＜0.05)，and the incidence of adverse reactions was 1.69% in the observation group，lower than that of 14.04% in the control group(P＜0.05). Conclusion： The application of Xue's Lijin Tongluo Bushen method for patients with calcaneodynia can effectively relieve the clinical symptoms and signs，enhance the curative effect，relieve the pain and improve the quality of life with high safety， which has obvious advantages when compared with that of routine blocking therapy.