Abstract： Objective： To observe the clinical effect of Shaofu Zhuyu granules combined with methotrexate for ectopic pregnancy. Methods：A total of 150 cases of patients with ectopic pregnancy were randomly divided into three groups，50 cases in each group. The treatment group was treated with Shaofu Zhuyu granules combined with methotrexate；the Control Group One was treated with Shaofu Zhuyu granules combined with Huoxue Huayu tang；the Control Group Two was simply treated with methotrexate. The clinical effect and the changes in serum β-HCG values and mass area，the clearance time of serum β-HCG and the average length of hospital stay after treatment in each group were observed and compared. Results： The total effective rate was 94.0% in the treatment group，and 82.0% in the Control Group One and the Control Group Two respectively；compared the one in the treatment group with those in the other two groups，there being significance in the difference(P＜0.05)；the curative effect in the Control Group One was comparable to that in the Control Group Two(P＞0.05). After treatment，the ratios of serum β-HCG which increases greater than or equal to 15% and of mass area which reduces greater than or equal to 30% in the treatment group were significantly higher than those in the other two groups(P＜0.05)；the clearance time of serum β- HCG and the average length of hospital stay were significantly shorter(P＜0.05)； there was no significant difference being found in the comparison of the above indexes between the Control Group One and the Control Group Two(P＞0.05). The overall incidence of adverse reactions was 20.0% in the treatment group， 12.0% in the Control Group One and 36.0% in the Control Group Two，differences being significant(P＜0.05)；there was no significant difference in the comparison between the treatment group and the Control Group One(P＞0.05). Conclusion： The therapy of Shaofu Zhuyu granules combined with methotrexate has significant curative effect in treating ectopic pregnancy，which can enhance the effect and reduce the toxicity to an extent.