Abstract：Objective：To observe the application effect of five-center service in humanized nursing care for children with measles. Methods： A total of 68 cases of children with measles were selected as the study objects， and divided into the observation group and the control group according to random number table method， 34 cases in each group. The control group was given routine humanized nursing care， and the observation group was additionally given five- center service intervention based on the nursing of the control group. The defervescence time， the time of eliminating measles and hospitalization time were compared between the two groups. The improvement of children's clinical symptoms and quality of life was observed，and the satisfaction of their parents towards humanistic care from nursing staffs was recorded. Results： The defervescence time，the time of eliminating measles and hospitalization time in the observation group were shorter than those in the control group，differences being significant(P＜0.01，P＜0.05). After nursing，in the two groups，the scores of rash onset on face，trunk and buccal mucosa，as well as fever were decreased when compared with those before nursing； the above four scores in the observation group were lower than those in the control group；differences were significant(P＜0.01， P＜0.05). After nursing， the scores of the attitude towards material life， social function， physical function and psychological state in the two groups were higher than those before nursing， differences being significant(P＜0.01)； the above scores in the observation group were higher than those in the control group，differences being significant(P＜0.01). In each dimension ，the scores of the satisfaction of their parents towards humanistic care from nursing staffs in the observation group were higher than those in the control group， differences being significant(P＜0.01). Conclusion： The application of five-center service in humanized nursing care for children with measles，can effectively shorten the defervescence time and the time of eliminating measles，improve their clinical symptoms and quality of life，as well as promote their rehabilitation， which is a kind of nursing intervention model with higher satisfaction.