Abstract：Objective：To observe the curative effect of Chinese herbal application combined with moxibustion for patients with advanced lung cancer and pleural effusion，and to discuss its nursing strategy. Methods：A total of 82 cases of patients with advanced lung cancer and pleural effusion in our hospital were randomly divided into two groups， 41 cases in each group. The control group was given injection of cisplatin and routine nursing； the observation group was additionally given Chinese herbal application，moxibustion and targeted nursing based on the treatment in the control group. The clinical effect， the depth of pleural effusion and the scores of Karnofsky Performance Status(KPS) were compared between the two groups. Results：The total effective rate was 68.29% in the observation group，significantly higher than that of 39.02% in the control group， the difference being significant(P＜0.05). After treatment， the depth of pleural effusion in the two groups was significantly decreased when compared with that before treatment，and the depth in the observation group was significantly smaller than that in the control group(P＜0.05). The score of KPS in the observation group was significantly increased when compared with that before treatment and was significantly higher than that in the control group(P＜0.05). In the control group， there was no significant difference being found in the comparison of the score of KPS before and after treatment(P＞0.05).Conclusion： The therapy of Chinese herbal application combined with moxibustion has definite curative effect in treating advanced lung cancer and pleural effusion. Combining the therapy with targeted nursing can promote the absorption of pleural effusion and improve health condition.