Abstract：Objective：To observe the clinical effect of oral administration of Qushi Qingchang prescription and enema with Qingre Lishi Guanchang prescription for chronic relapsing ulcerative colitis of large intestine dampness-heat type. Methods：A total of 80 cases of patients with chronic relapsing ulcerative colitis of large intestine dampness- heat type were randomly divided into two groups， 40 cases in each group. The treatment group was treated with oral administration of Qushi Qingchang prescription and enema with Qingre Lishi Guanchang prescription， and the control group was treated with mesalazine enteric-coated tablets. Both groups were treated for three courses，one month being a course. Before and after treatment，Chinese medicine syndrome scores were evaluated，and the levels of immunoglobulin including immunoglobulin M(IgM)， immunoglobulin A(IgA)， immunoglobulin G(IgG) were detected. After treatment， the clinical effect in the two groups was evaluated. Results：After treatment，the total effective rate in the treatment group was higher than that in the control group(P＜0.05). The Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment，and the above score in the treatment group was lower than that in the control group，differences being significant(P＜0.05). The IgG level in the control group was decreased when compared with that before treatment(P＜ 0.05)； the levels of IgM and IgG in serum in the treatment group were decreased when compared with those before treatment，and the levels in the treatment group were lower than those in the control group，differences being significant(P＜ 0.05). Conclusion： The application of oral administration of Qushi Qingchang prescription and enema with Qingre Lishi Guanchang prescription has definite curative effect in treating patients with chronic relapsing ulcerative colitis of large intestine dampness- heat type， which can effectively relieve the clinical symptoms of patients， regulate the immune function and enhance the curative effect.