Abstract：Objective：To observe the clinical effect of Huatan Tiaojing prescription for polycystic ovary syndrome(PCOS) of heat bind due to phlegm-dampness type. Methods：A total of 82 cases of PCOS patients were randomly divided into the control group and the treatment group， 41 cases in each group. The control group was treated with clomifene citrate to promote ovulation，and the treatment group was additionally treated with Huatan Tiaojing prescription based on the treatment of the control group. Both groups were treated for three menstrual cycles. Before and after treatment，the levels of estradiol (E2)，follicle-stimulating hormones(FSH)，luteinizing hormone(LH) and testosterone(T) in the two groups were observed and compared. The changes in ovarian volume and the number of basic antral follicles(AFC) before and after treatment were observed in the two groups. The recovery rate of menstrual cycle，ovulation rate and total clinical effect after treatment were compared between the two groups. Results：The total effective rate was 95.1% in the treatment group，and 65.9% in the control group，the difference being significant(P＜0.05). After treatment，the levels of sex hormones including E2，FSH，LH and T in the two groups were significantly improved when compared with those before treatment(P＜0.05)， and the improvement of above indexes in the treatment group was more significant than that in the control group(P＜0.05). After treatment，the ovarian volume and the number of AFC in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the above two indexes in the treatment group were less than those in the control group (P＜0.05). After treatment，the recovery rate of menstrual cycle and ovulation rate was 92.7% and 75.6% in the treatment group， and 68.3% and 48.8% in the control group， differences being significant(P＜0.05). Conclusion： The therapy of Huatan Tiaojing prescription combined with clomifene citrate has significant curative effect in treating PCOS. It can significantly improve the levels of sex hormones and menstrual cycle of patients， promote ovulation and decrease the ovarian volume and AFC.