Abstract：Objective：To observe the clinical effect of point application with Chinese herbal medicine for cancer related fatigue(CRF). Methods：A total of 120 cases of CRF patients were divided into the control group and the observation group according to the random number table method， 60 cases in each group. The control group was given routine nursing and symptomatic treatment， and the observation group was additionally given point application with Chinese herbal medicine based on the treatment of the control group. After two weeks and four weeks of treatment，the clinical effect and adverse reactions were evaluated； the scores of Revised Piper Fatigue Scale(PFS- R) and Quality of Life were compared； the enzyme-linked immunosorbent assay(ELISA) method was applied to detect the levels of interleukin-6(IL-6)，tumor necrosis factor- α(TNF- α)， interleukin- 1(IL- 1) and interferon- γ(IFN- γ) in serum； chemiluminescence immunoassay was used to detect the levels of adrenocorticotropic hormone(ACTH) and cortisol(C)；electrochemiluminescence immunoassay was used for detection of the level of adrenaline(AD). Results：After two-week treatment，the total effective rate was 81.67% in the observation group，higher than that of 63.33% in the control group(P＜0.05). After four-week treatment，the total effective rate was 95.00% in the observation group， higher than that of 71.67% in the control group(P＜0.05). In the observation group，the total effective rate after four-week treatment was higher than that after two-week treatment(P＜0.05). After two weeks and four weeks of treatment，the scores of behavior，affection，sensory，cognition，and mood in both groups were gradually decreased(P＜0.05)， the differences within the group were statistically significant(P＜0.05)； each score in the observation group was lower than that in the control group at the same time point(P＜0.05). After two weeks and four weeks of treatment，the scores of body，role，cognition，mood and social skills in the two groups were gradually increased(P＜ 0.05)，the differences within the group were statistically significant(P＜0.05)；the above five scores in the observation group were significantly higher than those in the control group at the same time point(P＜0.05). After two weeks and four weeks of treatment，the levels of IL-6，TNF-α，IL-1 and IFN-γ in serum in the two groups were gradually decreased(P＜0.05)，the differences within the group were statistically significant(P＜0.05)；the above four levels in serum in the observation group were all lower than those in the control group in the same period(P＜0.05). After two weeks and four weeks of treatment，the levels of ACTH and AD in the two groups were gradually decreased，and the levels of C were gradually increased(P＜0.05)； the differences within the group were statistically significant(P＜0.05)；the levels of ACTH and AD in the observation group were lower than those in the control group at the same time point， and the level of C was higher， differences being significant(P＜0.05). The incidence of adverse reactions was 26.67% in the observation group， and 28.33% in the control group， there was no significance in the difference(χ2=164， P=0.685). Conclusion： Point application with Chinese herbal medicine has good clinical effect on CRF，which can significantly improve the levels of cytokine and endocrine hormone in nerve，with high safety.