Abstract：Objective：To observe the clinical effect of Bushen Jianpi prescription combined with routine therapy for acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods：A total of 60 cases of patients with AECOPD of lung- spleen qi deficiency type were randomly divided into the control group and the observation group， 30 cases in each group. Both groups were treated with routine therapy，and the observation group was additionally treated with Bufei Jianpi prescription. Both groups were treated for seven days. Before and after treatment， the scores of COPD Assessment Test (CAT)， Breathlessness measurement using the modified British Medical Research Council(mMRC)， infective inflammation indexes including procalcitonin(PCT) and C-reactive protein(CRP)，the indexes of blood gas analysis including partial pressure of oxygen(PaO2)， partial pressure of carbon dioxide(PaCO2) and oxygen saturation(SaO2)， and the Chinese medicine syndrome scores were evaluated and detected in the two groups. The clinical effect was compared between the two groups. Results：After treatment，the clinical effect in the observation group was superior to that in the control group(P＜0.05). The total score and each score of CAT in the two groups were decreased when compared with those before treatment(P＜0.01)， and the above scores in the observation group were all lower than those in the control group(P＜0.05). The activity intensity causing dyspnea in the two groups were increased when compared with that in the same group before treatment(P＜0.05)； the activity intensity in the observation group was higher than that in the control group(P＜0.05). The levels of PCT and CRP in peripheral blood in the two groups were decreased when compared with those before treatment(P＜0.01)，and the levels in the observation group were lower than those in the control group(P＜0.05). The levels of PaO2 and SaO2 in the two groups were increased when compared with those before treatment(P＜0.01)， and the levels of PaCO2 were decreased when compared with those before treatment(P＜0.01). The levels of PaO2 and SaO2 in the observation group were higher than those in the control group(P＜0.01)，and the level of PaCO2 in the observation group was lower than that in the control group(P＜ 0.01). Each syndrome score of lung- spleen qi deficiency syndrome and the total score in the observation group were decreased when compared with those before treatment(P＜0.01). The scores of cough， expectoration， dyspnea， chest distress and short breath as well as the total score in the control group were decreased when compared with those before treatment(P＜0.01)；when compared the scores of torpid intake，spontaneous sweating and abdominal distention before and after treatment in the control group，there was no significance in the difference(P＞0.05). Each syndrome score and the total score in the observation group were lower than those in the control group(P＜0.05). Conclusion：The therapy of Bushen Jianpi prescription combined with routine therapy for AECOPD can more effectively control infective inflammation，and meanwhile， significantly improve airflow obstruction and hypoxia，further relieve clinical symptoms，and enhance the quality of life，with very positive effect on the control of AECOPD.