Abstract：Objective：To observe the effect of integrated prevention and treatment in Chinese medicine on quality of life in patients undergoing radiotherapy for head and neck cancer. Methods：A total of 80 patients were randomly divided into the observation group and the control group， 40 cases in each group. The control group was given symptomatic treatment of rinse containing according to their condition， and was given corresponding diet nursing， psychological nursing and health education. The observation group rinsed with Yinlian gargle， and received diet nursing and emotional nursing. In the two groups， the prevention and treatment measures were carried out at the same time with radiotherapy until the end of radiotherapy(about eight weeks). At the end of radiotherapy， the degree of oral stomatitis， the scores of Visual Analogue Scale(VAS) for evaluating the degree of pain，and the degree of radiation-induced dysphagia were counted in the two groups. Before treatment and at the end of radiotherapy respectively，the scores of quality of life questionnaire for Chinese cancer patients(QLQ) and the Symptom Checklist- 90(SCL- 90) were evaluated. Results： During radiotherapy， the degree of oral stomatitis and the degree of radiation-induced dysphagia in the observation group were less than those in the control group (P＜0.05). The days of the scores of VAS less than or equal to 4 in the observation group were less than those in the control group(P＜0.01)，the average and the highest scores of VAS in the observation group were both lower than those in the control group(P＜0.01). The scores of QOC and SCL- 90 in the two groups were decreased when compared with those before treatment(P＜0.01). The score of QOC in the observation group was higher than that in the control group(P＜0.01)，and the score of SCL- 90 was lower(P＜0.01). Conclusion： The concurrent application of integrated prevention and treatment in Chinese medicine to the patient undergoing radiotherapy for head and neck cancer， can decrease the degree of oral stomatitis，pain，and dysphagia，and improve their psychological status，thus it can maintain or improve their quality of life.