Abstract： Objective： To observe the clinical effect of modified Xinglou Chengqi tang for acute cerebral infarction with phlegm-heat bowel excess syndrome. Methods：A total of 123 cases of patients with acute cerebral infarction with phlegmheat bowel excess syndrome were divided into the observation group and the control group according to the random number table method， 82 and 41 cases in each group respectively. Both groups were given treatments such as antiplatelet aggregation and thrombolysis，the control group was additionally treated with lactulose oral liquid，and the observation group was treated with modified Xinglou Chengqi tang. Both groups were treated for seven days. The levels of interleukin- 6(IL-6)， Chinese medicine syndrome scores and the scores of National Institutes of Health Stroke Scale(NIHSS) before and after treatment were compared between the two groups. After treatment， the clinical effect was compared between the two groups. Results：After treatment，the levels of IL- 6 in the two groups were decreased when compared with those before treatment(P＜0.01)， but there was no significance in the difference among the two groups(P＞0.05). After treatment， the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜ 0.01)， and the scores in the observation group were lower than those in the control group(P＜0.01). After treatment， the scores of NIHSS in the two groups were decreased when compared with those before treatment(P＜0.01)；the score in the observation group was lower than that in the control group(P＜0.01). The total effective rate was 93.90% in the observation group， higher than that of 80.49% in the control group， the difference being significant(P＜0.05). Conclusion： Modified Xinglou Chengqi tang for patients acute cerebral infarction with phlegm-heat bowel excess syndrome，can effectively relieve the clinical effect of them，improve the neurological function and reduce inflammatory reactions.