Abstract： Objective： To observe the clinical effect of Yixinshu tablets based on conventional treatment of western medicine and Zhigancao tang on frequent premature ventricular contractions. Methods：A total of 96 patients with frequent premature ventricular contractions in type of deficiency of both qi and yin were randomly divided into the treatment group and the control group，48 patients in each group. The two groups were treated with western medicine and Zhigancao tang，and the treatment group was additionally treated with Yixinshu tablets. The treatment course of both groups was five weeks. The clinical effect， the improvement of frequency of premature ventricular contractions and the incidence of adverse reactions were compared between the two groups. Results： After treatment， the total effective rate was 97.92% in the treatment group and 79.17% in the control group， the difference being significant(P＜0.01). The frequency of premature ventricular contractions in 24 h dynamic electrocardiogram in both groups was respectively decreased when compared with that before treatment(P＜0.05). The frequency of premature ventricular contractions in the treatment group was less than that in the control group(P＜0.05). The difference value of the frequency of premature ventricular contractions before and after treatment was higher in the treatment group than in the control group(P＜0.01). Conclusion：Based on the conventional treatment of western medicine and Zhigancao tan， the additional application of Yixinshu tablets for frequent premature ventricular contractions，can effectively improve the clinical symptoms，such as palpitations，chest distress，shortness of breath，and significantly reduce the frequency of premature ventricular contractions.