Abstract： Objective： To observe the clinical effect of Bushen Yijing tang combined with pancreatic kininogenase for patients with oligospermia with kidney meridian deficiency syndrome. Methods： A total of 120 cases of patients with oligospermia with kidney meridian deficiency syndrome were randomly divided into two groups，60 cases in each group. The control group was treated with pancreatic kininogenase， and the observation group was additionally treated with Bushen Yijing tang based on the treatmentof the control group. The sperm quality，changes in the levels of luteinizing hormone(LH)， follicle stimulating hormone(FSH)，estrogen(E2)，and testosterone(T) in serum before and after treatment，and the reactive oxygen species(ROS)，malondialdehyde(MDA) and superoxide dismutase(SOD) in semen and seminal plasma as well as the levels of internal environment-related indexes including acid phosphatase(ACP)，adenylate cyclase(AC) and phosphodiesterase (PDE) in seminal plasma after treatment in the two groups were observed and compared. Results： The total effective rate was 90.0% in the observation group and 73.3% in the control group， the difference being significant(P＜0.05). After treatment，the sperm density，a level，a+b level and a+b+c level of activity，and sperm normal morphology rates in the two groups were significantly improved when compared with those before treatment(P＜0.05)，and the improvement of the above indexes in the treatment group was more significant than that in the control group(P＜0.05). Before and after treatment，there was no significant difference in the comparison of changes in semen volume between the two groups(P＞ 0.05). After treatment，the levels of T，E2，FSH and LH in the two groups were significantly increased when compared with those before treatment(P＜0.05)，and the above levels in the observation group were higher than those in the control group (P＜0.05). After treatment，the levels of ROS and MDA in the observation group were lower than those in the control group， and SOD level was higher， differences being significant(P＜0.05). After treatment， the levels of ACP and AC in the observation group were higher than those in the control group，and PDE level was lower，differences being significant(P< 0.05). Conclusion：The therapy of Bushen Yijing tang combined with pancreatic kininogenase for patients with oligospermia with kidney meridian deficiency syndrome can improve the number and quality of sperm， reduce the oxidative stress responses，and improve the internal environment of sperm.