Abstract：Objective：To observe the curative effect of Tiaoxin Anshen needling method combined with routine western medicine for arrhythmia. Methods：A total of 158 cases of patients with arrhythmia were selected and randomly divided into the experiment group and the control group，79 cases in each group. The control group was given routine western medicine， and the experiment group was given Tiaoxin Anshen needling method based on the treatment of the control group. Both groups were treated for two weeks. The curative effect in the two groups was observed；the heart function indexes including left ventricular ejection fraction(LVEF) and left ventricular end- diastolic diameter(LVEDD) ， the indexes of the heart rate variability such as high frequency power(HF)， low frequency power(LF)， the root mean square of the successive differences of sinus inter-beat interval(RMSSD)，and the standard deviation of the averages of normal-to-normal inter-beat interval of sinus in all 5-minute segments(SDANN)，as well as apoptosis indexes including C-myc and Bcl- 2 protein in the two groups before treatment were compared with those after two- week treatment. During the six- month follow- up，the recurrence rate and scores of the World Health Organization Quality of Life Assessment-Brief Version(WHOQOL-BREF) were compared between the two groups. Results：The total effective rate was 94.94% in the experiment group，higher than that of 83.54% in the control group(P＜0.05). After two-week treatment，LVEF，HF，LF，RMSSD and SDANN，as well as Bcl- 2 levels in the two groups were increased when compared with those before treatment，and the five indexes and the level in the experiment group were higher than those in the control group； LVEDD and C- myc levels in the two groups were decreased when compared with those before treatment，and the index and the level in the experiment group were lower than those in the control group(P＜0.05). In the six month after treatment，the scores of WHOQOL-BREF in the two groups were increased when compared with those before treatment，and the score in the experiment group was higher than that in the control group(P＜0.05). During the six-month follow-up，the recurrence rate was 2.67%(2/75) in the experiment group and 15.15% (10/66) in the control group， the difference being significant among the two groups(P＜0.05). Conclusion： The application of Tiaoxin Anshen needling method combine with routine western medicine in treating arrhythmia， can significantly promote curative effect and quality of life，improve the heart function and the heart rate variability，increase the protein expression of C-myc and Bcl-2，and inhibit apoptosis，as well as reduce the recurrence rate.