Abstract： Objective： To observe the clinical effect of modified Daotan tang and Shentong zhuyu tang combined with lenalidomide/dexamethasone(RD) regimen for multiple myeloma(MM). Methods： A total of 60 cases of MM patients with phlegm-stasis-obstructing arthralgia syndrome were randomly divided into the observation group and the control group，30 cases in each group. Both groups were given lenalidomide capsules and dexamethasone tablets，and the observation group was additionally given oral administration of modified Daotan tang and Shentong zhuyu tang at the same period. Both groups were treated for two courses. The curative effect was evaluated on the 60th day after the first chemotherapy. Before and after treatment， the degree of bone pain was evaluated by Visual Analogue Scale(VAS)； the score of Karnofsky Performancec Status(KPS) was evaluated； the incidence of adverse reactions was recorded and evaluated systematically via the National Cancer Institute Common Toxicity Criteria for Adverse Event(NCI- CTC AE). The clinical effect in the two groups was compared. Results：After treatment，the clinical effect in the observation group was better than that in the control group(P＜ 0.05). The scores of VAS of bone pain and KPS in the two groups were decreased when compared with those before treatment (P＜0.01). The VAS score of bone pain in the observation group was lower than that in the control group(P＜0.01)，and the KPS score was higher(P＜0.01). The incidences of gastrointestinal reactions and hematological toxicity in the observation group were lower than those in the control group(P＜0.05)；when compared the incidence of peripheral neuropathy，rash and back pain between the two groups，there was no significance in differences among the two groups(P＞0.05). Conclusion：As for the treatment of MM patients with phlegm-stasis-obstructing arthralgia syndrome，the therapy of modified Daotan tang and Shentong zhuyu tang combined with RD regimen can more effectively relieve pain， reduce the adverse reactions of chemotherapy，and improve life quality and clinical effect.