Abstract： Objective： To observe the clinical effect of tongtian intradermal injection combined with levodopa and benserazide tablets for Parkinson disease(PD) and its effect on blood stasis. Methods：A total of 60 cases of PD patients were randomly divided into the observation group and the control group，30 cases in each group. The control group was given levodopa and benserazide tablets，and the observation group was additionally treated with tongtian intradermal injection based on the treatment of the control group. Both groups were treated for three months. Before and after treatment，the levels of lipid peroxide(LPO)，superoxide dismutase(SOD)，interleukin-1β(IL-1β)，tumor necrosis factor-α (TNF- α ) ， fibrinogen(FBG) ， D- dimer(D- D) and blood platelet count(BPC) in serum ， as well as dopamine(DA) and 5- hydroxytryptamine(5- HT) in the brain were detected in the two groups. The scores of blood stasis syndrome before and after treatment were recorded in the two groups. The scores of modified Webster Rating Scale before and after treatment， and the clinical effect after treatment were compared between the two groups. Results：After treatment，the levels of IL-1β， TNF- α，FBG，D- D and BPC in serum in the two groups，as well as the levels of LPO and SOD in the observation group were decreased when compared with those before treatment(P＜0.05)；the seven serum indexes above in the observation group were lower than those in the control group(P＜0.05). After treatment，the levels of DA and 5- HT in the brain in the observation group were increased when compared with those before treatment，higher than those in the control group after treatment，differences being significant(P＜0.05). In the control group，there was no significance being found in differences when compared the levels of DA and 5-HT in the brain with those before and after treatment(P＞0.05). After treatment，the scores of limb shaking，tongue manifestation，pulse condition，lip color，subdermal ecchymosis，and scaly skin in the two groups were decreased when compared with those before treatment(P＜0.05)，and the decrease in six scores of blood stasis syndrome above in the observation group were more significant than those in the control group(P＜0.05). After treatment，the scores of modified Webster Rating Scale in the two groups were decreased when compared with those before treatment(P＜ 0.05)，and the decrease in the observation group was more significant than that in the control group(P＜0.05). In the followup six months after the treatment，the scores of modified Webster Rating Scale in the observation group were lower than those in the control group(P＜0.05). The total effective rate was 93.3% in the observation group，higher than that of 76.7% in the control group(P＜0.05). Conclusion：In the treatment of PD，the therapy of tongtian intradermal injection combined with levodopa and benserazide tablets can improve clinical effect and resolve blood stasis.