Abstract： Objective： To observe the clinical effect of Huatan Jiangzhuo prescription combined with routine western medicine for angina pectoris in coronary heart disease with turbid phlegm obstruction syndrome. Methods：A total of 96 cases of patients with angina pectoris in coronary heart disease with turbid phlegm obstruction syndrome were divided into the control group and the observation group according to the random number table method，48 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with Huatan Jiangzhuo prescription based on the treatment of the control group. Before and after treatment， the scores of main and secondary symptoms and the total scores in the two groups were compared. The changes in indexes of blood lipid and hemorheology as well as clinical effect and adverse reactions were observed. Results：After treatment，the scores of main and secondary symptoms and the total scores in the two groups were decreased when compared with those before treatment(P＜0.05)， and the scores in the observation group were lower than those in the control group(P＜0.05). After treatment，triglyceride (TG)， serum total cholesterol(TC)， low density lipoprotein cholesterol(LDL- C)， plasma viscometry(PV)， whole blood viscosity(WBV)，erythrocyte aggregation index(AI) and hematocrit(HCT) in the two groups were decreased when compared with those before treatment(P＜0.05)，and the indexes in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of high-density lipoprotein cholesterol(HDL-C) in the two groups were increased when compared with those before treatment，and the one in the observation group was higher than that in the control group(P＜ 0.05). The total effective rate was 89.58% in the observation group，higher than that of 72.92% in the control group，the difference being significant(P＜0.05). The incidence of adverse reactions was 14.58% in the observation group and 8.33% in the control group， there being no significance in the difference(P＜0.05). Conclusion： Huatan Jiangzhuo prescription combined with routine western medicine can effectively relieve the symptoms of patients with angina pectoris in coronary heart disease with turbid phlegm obstruction syndrome and regulate the indexes of blood lipid and hemorheology with good curative effect.