Abstract：Objective：To observe the effect of Huotan Xijing tang combined with acupuncture on neurological function， neuron- specific enolase(NSE) and serum brain- derived neurotrophic factor(BDNF) in patients with epilepsy secondary to cerebral infarction. Methods：A total of 80 cases of patients with epilepsy secondary to cerebral infarction were divided into the observation group and the control group according to the random number table method，40 cases in each group. Both groups were given routine western medicine for symptomatic treatment； the control group was additionally treated with acupuncture， and the observation group was additionally treated with Huotan Xijing tang based on the treatment of the control group. The changes in the clinical effect，National Institute of Health Stroke Scale(NIHSS) scores and Barthel indexes in the two groups were compared，and the levels of NSE，BDNF and inflammatory factors were detected. Results：The total effective rate was 92.50% in the observation group，higher than that of 75.00% in the control group，the difference being significant(χ2=4.501，P=0.034<0.05). Before treatment，there was no significant difference being found in the comparison of the NIHSS scores and Barthel indexes between the two groups(P＞0.05). After treatment，NIHSS scores in the two groups were decreased when compared with those before treatment，and Barthel indexes were increased；the NIHSS score in the observation group was lower than that in the control group， and Barthel index was higher， differences being significant (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of NSE，BDNF， interleukin- 1β(IL-1β)，interleukin- 2(IL-2) and tumor necrosis factor- α(TNF- α) between the two groups(P＞0.05). After treatment，the levels of NSE，IL-1β，IL-2 and TNF-α in the two groups were decreased when compared with those before treatment，and BDNF levels were increased；the levels of NSE，IL-1β，IL-2 and TNF-α in the observation group were lower than those in the control group，and BDNF level was higher，differences being significant(P＜0.05). Conclusion：The therapy of Huotan Xijing tang combined with acupuncture can improve the neurological function of patients with epilepsy secondary to cerebral infarction， reduce inflammatory factors， regulate the expression levels of NSE and BDNF， and enhance the ability of daily life.