Abstract：Objective：To discuss the application of Shugan Jieyu capsules combined with physical therapy on patients with anxiety and depression and its effect on their stress response. Methods：A total of 104 cases of patients with anxiety and depression were divided into the study group and the control group by sealed envelope method，52 cases in each group. The control group was treated with Shugan Jieyu capsules，and the study group was additionally treated with physical therapy based on the treatment of the control group. Both groups were treated for four months. The levels of stress hormone，the scores of anxiety and depression and clinical effect were observed and compared between the two groups. Results：The total clinical effective rate was 94.2% in the study group，higher than that of 84.6% in the control group，the difference being significant(χ2=7.154，P＜0.05). Before treatment，compared the levels of adrenocorticotropic hormone(ATCH)，corticotropin releasing hormone(CRH)， cortisol(CORT) and human growth hormone(HGH) between the two groups， there was no significance in the difference(P＞0.05). After treatment， the levels of ACTH， CRH and CORT in the two groups were decreased when compared with those before treatment， and the levels of HGH were increased(P＜0.05)； the levels of ACTH，CRH and CORT in the study group were lower than those in the control group，and the level of HGH was higher (P＜0.05). Before treatment，compared the scores of Hamilton Anxiety Scale(HAMA- 14) as well as Hamilton Depression Scale(HAMD-17) between the two groups，there was no significance in the difference(P＞0.05). After treatment，the scores of HAMA-14 and HAMD-17 in the two groups were decreased when compared with those before treatment，and the two scores in the study group were lower than those in the control group，differences being significant(P＜0.05). Conclusion： The therapy of Shugan Jieyu capsules combined with physical therapy has defined effect in treating patients with anxiety and depression，which can regulate the levels of stress response indexes and improve the scores of anxiety and depression.