Abstract：Objective：To observe the curative effect of fire needle combined with fumigation and washing with Shufu powder for psoriasis. Methods：A total of 200 cases of patients with psoriasis were selected as the study subjects and divided into the observation group and the control group according to the envelope method，100 cases in each group. The control group was treated with fire needle，and the observation group was additionally treated with fumigation and washing with Shufu powder based on the treatment of the control group. Before and after treatment，the symptom scores，the area of psoriatic lesions，the scores of Psoriasis Area and Severity Index(PASI)，serum indexes and the levels of inflammatory factors in the two groups were compared. The curative effect，incidences of adverse reactions and the recurrence in the two groups were compared. Results：The total effective rate of treatment was 96.00% in the observation group，higher than that of 84.00% in the control group，the difference being significant(P＜0.05). After treatment，the scores of erythema，scales， pruritus and PASI in the two groups were decreased(P＜0.05)，and the above scores in the observation group were lower than those in the control group(P＜0.05)；the levels of vascular endothelial growth factor(VEGF)，malondialdehyde(MDA) and lipid peroxide(LPO) in the two groups were decreased(P＜0.05)，and the above levels in the observation group were all lower than those in the control group(P＜0.05). The levels of interleukin-6(IL-6)，interleukin-8(IL-8)，tumor necrosis factor-α (TNF-α) in the two groups were decreased(P＜0.05)，the levels of IL-6，IL-8 and TNF-α in the observation group were lower than those in the control group(P＜0.05). The incidence of adverse reactions was 5.00%(5/100) in the observation group and 8.00%(8/100) in the control group，there being no significance in the difference(P＞0.05). After six-month follow- up， the recurrence rate was 2.08%(2/96) in the observation group and 11.90%(10/84) in the control group，the difference being significant(P＜0.05). Conclusion：The therapy of fire needle combined with fumigation and washing with Shufu powder for psoriasis has definite curative effect，and can significantly improve the clinical symptoms of patients as well as reduce their systemic inflammatory responses and the recurrence rate of psoriasis，which is safe and effective.