Abstract：Pain often brings discomfort to patients. The management of pain has always been a hot and difficult research topic. Drug dependence and adverse reactions are prone to occur in patients who use drugs to relieve pain，while wrist-ankle acupuncture has been proved to have better analgesic effect. The authors reviewed the concept of wrist-ankle acupuncture， discussed the pain mechanism from meridian theory， neurohumoral theory， and biological theory， and summarized the application of wrist-ankle acupuncture in the fields of acute pain，chronic pain，cancer pain，and postoperative pain，so as to provide reference for clinical practice.