Abstract：Objective：To observe the clinical effect of the therapy of Chinese medicine emotional nursing combined with conventional medical nursing measures on the intervention of bipolar disorder. Methods：Eighty patients with bipolar disorder were divided into the control group and the observation group according to the random number table method，40 cases in each group. The atypical patients in both groups took olanzapine tablets orally，while the typical patients took magnesium valproate tablets and were given comprehensive nursing measures such as diet nursing， psychological nursing and rehabilitation nursing. Patients in the observation group were adopted with Chinese medicine emotional nursing based on the different characteristics of each patient，including the psychotherapy of complying with emotional and psychological needs， the psychotherapy of changing emotions，the psychotherapy of one emotion suppressing another and the psychotherapy of tranquilizing and sedating the mind. Both groups took medicine continuously，and the nursing measures were carried out two to four times a week according to the situation，and were observed for eight weeks. The score of Hamilton Depression Scale (HAMD)， Self- rating Depression Scale(SDS)， Self- Rating Anxiety Scale(SAS) and Bech- Rafaelsdn Mania Rating Scale (BRMS) were assessed before and after eight-week treatment. The nursing satisfaction was evaluated on the day of discharge. Results：After treatment，the scores of HAMD，BRMS，SDS and SAS in the two groups were all decreased when compared with those before treatment(P＜0.01)，and the above four scores in the observation group were lower than those in the control group(P＜0.01). The score of nursing satisfaction in the observation group was higher than that in the control group(P＜0.05). Conclusion： Based on the treatment of conventional medical nursing measures， the additional application of Chinese medicine emotional nursing can further improve the mental health of patients with bipolar disorder， reduce depression，anxiety，and thus reduce the degree of depression and manic symptoms.