Abstract： Objective： To observe the clinical effect of modified Xiaoyao powder combined with western medicine for post-stroke depression. Methods：A total of 100 cases of patients with post-stroke depression were randomly divided into the control group and the observation group，50 cases in each group. Based on routine treatment，the control group was additionally treated with fluoxetine hydrochloride capsules，and the observation group was additionally treated with modified Xiaoyao powder based on the treatment of the control group. Both groups were treated for two months. Before and after treatment，the changes in scores of Hamilton Depression Scale(HAMD) in the two groups were observed and compared， and the clinical effect in the two groups was evaluated. Results：The total effective rate was 92.0% in the observation group and 72.0% in the control group，the difference being significant(P＜0.05). After treatment，the HAMD scores in the two groups were significantly decreased when compared with those before treatment(P＜0.05)； the HAMD score in the observation group was significantly lower than that in the control group(P＜0.05). Conclusion：Modified Xiaoyao powder for post-stroke depression has definite curative effect and can effectively improve depression of patients.