Abstract：Objective：To observe the clinical effect of comprehensive therapy of Chinese medicine combined with human chorionic gonadotropin(HCG) for infertility caused by luteal phase defect. Methods： A total of 90 cases of patients with infertility caused by luteal phase defect were divided into the control group and the observation group according to the random number table method， 45 cases in each group. The control group was given intramuscular injection with HCG， and the observation group was additionally treated with moxibustion on ginger and Bushen Huoxue prescription based on the treatment of the control group. During the mid-luteal phase，the changes in blood flow indexes of ovarian artery and luteal function in the two groups were observed. Results：The total effective rate was 95.56% in the observation group，higher than that of 71.11% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the levels of estradiol(E2)，progesterone(P) and luteinizing hormone(LH) during the mid-luteal phase between the two groups(P＞0.05). After treatment，the levels of E2，P and LH during the midluteal phase in the two groups were increased when compared with those before treatment(P＜0.05)，and the levels in the observation group were higher than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of pulsatility index(PI)， resistance index(RI)， peak systolic velocity(PSV) and end diastolic velocity(EDV) between the two groups(P＞0.05). After treatment， the RI levels in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of PSV and EDV were increased(P＜0.05)；the RI level in the observation group was lower than that in the control group(P＜0.05)，and the levels of PSV and EDV were higher(P＜0.05). Conclusion： Comprehensive therapy of Chinese medicine for patients with infertility caused by luteal phase defect can improve the blood perfusion of ovarian artery and sex hormone levels，thus improving luteal function and pregnancy rate.