Abstract：Objective：To observe the clinical effect of press- needle combined with Duhuo Jisheng tang for piriformis syndrome. Methods：A total of 82 cases of patients with piriformis syndrome were divided into the control group and the observation group according to the random number table method，41 cases in each group. The control group was treated with Duhuo Jisheng tang，and the observation group was additionally treated with press- needle based on the treatment of the control group. The clinical effect in the two groups was compared. The scores of Oswestry Disability Index(ODI) and McGill Pain Questionnaire before and after treatment were recorded. Results：The total effective rate was 95.12% in the observation group，higher than that of 80.49% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the scores of ODI and McGill Pain Questionnaire between the two groups(P＞0.05). After treatment，the scores of ODI and McGill Pain Questionnaire in the two groups were decreased when compared with those before treatment，and the above scores in the observation group were lower than those in the control group， differences being significant(P＜0.05). Conclusion： press- needle combined with Duhuo Jisheng tang has significant curative effect in treating piriformis syndrome，and can effectively improve dysfunction and relieve pain.