Abstract： To review the etiology， pathogenesis and treatment of cancer related fatigue(CRF) from the perspective of both Cinese medicine and westem medicine. The etiology and pathogenesis of CRF are complex. Modern medicine believes that it may relate to the influence of tumor itself， tumor related treatment， complications， immunity and inflammation， central nervous system dysfunction， hypothalamic regulatory circuit disorder， dysfunction of skeletal muscles and mitochondria as well as gene diversity. Its treatment measures are mainly non- medication. In Chinese medicine， CRF belongs to the category of consumptive disease，whose main pathogeneses are viscera-bowels depletion，deficiency of qi， blood，yin and yang and long-term deficiency causing fatigue，and whose disease locations are mainly the spleen，kidney and liver. Chinese medicine has unique advantages and significant curative effect in improving and treating CRF.