Abstract：Objective：To observe the clinical effect of Pingchan tang combined with memantine hydrochloride tablets for Parkinson disease of liver-kidney deficiency type. Methods：A total of 120 cases of patients with Parkinson disease of liverkidney deficiency were selected and divided into the control group and the observation group according to the random number table method， 60 cases in each group. Both groups were given routine symptomatic treatment based on condition after admission. The control group was given memantine hydrochloride tablets，and the observation group was additionally given Pingchan tang based on the treatment of the control group. Cognitive function， motor function， and the differences of inflammatory factors indexes， α- synuclein(α- SYN) and the contents of lipid peroxide(LPO) and malondialdehyde(MDA) in serum before and after treatment were compared between the two groups. The clinical effect and the incidence of adverse reactions were counted and analyzed. Results： The total effective rate was 86.67% in the observation group， higher than that of 71.67% in the control group，the difference being significant(P＜0.05). After treatment，the scores of Mini- Mental State Examination(MMSE) in the two groups were increased when compared with those before treatment，and the score in the observation group was higher than that in the control group，differences being significant(P＜0.05). After treatment，the scores of Unified Parkinson Disease Rating Scale Ⅱ(UPDRSⅡ) and Ⅲ(UPDRSⅢ) in the two groups were decreased when compared with those before treatment，and the scores of UPDRSⅡand UPDRSⅢ in the observation group were lower than those in the control group， differences being significant(P＜0.05). After treatment， the levels of tumor necrosis factor- α (TNF-α)，interleukin-6(IL-6)，interleukin-8(IL-8)，α-synuclein，LPO and MDA in serum were decreased when compared with those before treatment，and the six levels in serum in the observation group were lower than those in the control group (P＜0.05). Conclusion：The application of Pingchan tang combined with memantine hydrochloride tablets in treating patients with Parkinson disease of liver-kidney deficiency type，can reduce their systemic inflammatory response，improve systemic stress state，and conduce to the recovery of cognitive function，with better safety.