Abstract： Objective： To observe the effect of the therapy of early exercise combined with Chinese medicine rehabilitation on the cardiac function and quality of life of patients with acute myocardial infarction(AMI) after emergency percutaneous coronary intervention(PCI). Methods： A total of 200 patients diagnosed with AMI who underwent PCI were divided into two groups according to the random number table method，100 cases in each group. The control group received routine nursing and rehabilitation guidance，and the study group additionally received the therapy of early exercise combined with Chinese medicine rehabilitation based on the treatment of the control group. Before and after intervention，the cardiac blood volume index，cardiac function index and 6 min walking distance as well as the score of quality of life in the two groups were compared. Results：After intervention，the blood volume index in the two groups was improved respectively(P＜0.05)， and the one in the study group was better than that in the control group(P＜0.001). After intervention，the cardiac function index and 6 min walking distance in the study group were better than those in the control group(P＜0.001). Before intervention， there was no statistically significant difference in the comparison of score of quality of life between the two groups(P＞0.05). After intervention，the score of quality of life in the study group were better than those in the control group (P＜0.05). Conclusion：In treating AMI patients who underwent PCI，the therapy of early exercise combined with Chinese medicine rehabilitation can significantly improve the cardiac function index，6 min walking distance and quality of life.